Systemic folinate calcium, a folic acid derivative, and topical diet vitamin B12 have found to be effective in treating psoriasis. Tea tree is a plant believed to treat inflammatory skin conditions. It works as an antiseptic and can alleviate the inflammation and redness associated with scalp psoriasis.
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There may be a link between the oxidative stress state in psoriasis and the effect of HHcy. Hydrogen sulfide may play a protective role in the pathogenesis of psoriasis and the deficiency of H2S in psoriasis may be caused by HHcy. As the role of Hcy in the pathogenesis of psoriasis is most likely established, Hcy can be a potential therapeutic target for the treatment of psoriasis.
Recent studies have demonstrated that patients with psoriasis have a significantly higher serum homocysteine level and a higher prevalence of hyperhomocysteinaemia . Insufficiency of folic acid and vitamin B12 can be a cause of HHcy in psoriasis. Hcy may promote the immuno-inflammatory process in the pathogenesis of psoriasis by activating Th1 and Th17 cells and neutrophils, while suppressing regulatory T cells. Moreover, Hcy can drive the immuno-inflammatory process by enhancing the production of the pro-inflammatory cytokines in related to psoriasis. Hcy can induce nuclear factor kappa B activation, which is critical in the immunopathogenesis of psoriasis.
It’s important to note that home remedies can help ease symptoms but they’re not proven cures. The following home treatments are generally safe and may help you reduce the symptoms of mild to moderate scalp psoriasis. Those with more aggressive forms of the condition should consult a doctor before starting home treatment. Most doctors recommend topical medications, light therapy, and medications that affect the entire body to treat scalp psoriasis.
Be aware that some people are allergic and sensitive to tea tree oil, and the substance has been linked to hormone changes in some people. Several studies demonstrate that the function of Tregs is impaired in psoriasis and treatments for psoriasis may increase the number and activity of Treg . Studies showed that HHcy impaired the suppressive function of Tregs in vitro and in vivo.
In patients with rheumatoid arthritis , during MTX treatment a significant rise in plasma Hcy was seen. In general, this effect could be reversed by folate administration .
- If you do eat red meat, try to stick to lean cuts, avoiding fattier meats and cuts.
- According to these practitioners, this syndrome occurs when the lining of the intestines becomes damaged.
- The lining is unable to prevent waste products from leaking out into the bloodstream due to the damage.
- Proponents of this syndrome believe the leak in the gut triggers an autoimmune response.
- Harvard Health also says that certain red meats can cause inflammation, including burgers, steaks, hot dogs and sausage.
- This response may lead to a collection of systemic health problems.
On the other hand, systemic folinate calcium, a folic acid derivative, and topical vitamin B12 have found to be effective in treating psoriasis. A plant-derived compound quercetin which also can lower Hcy levels has been found to have anti-psoriatic effect in animal models. Preclinical studies have indicated the potential of some H2S donors as therapeutic agents for treatment of psoriasis in the future. Psoriasis is caused by a complex interplay among the immune system, genetic background, autoantigens, and environmental factors.
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Presumably, MTX may also increase plasma Hcy in psoriasis patients. It is well established that folic acid supplementation has a role in the treatment of psoriasis in conjunction with MTX treatment . Plasma vitamine B12 levels were not affected by MTX treatment in RA patients . Scalp psoriasis is a chronic skin condition caused by issues with the immune system.
The possible role of MTX in psoriasis is related to its role in inhibiting dihydrofolate reductase and, therefore, in the activation of folic acid. This leads to the inhibition of the synthesis of DNA. By inhibiting DNA synthesis, MTX limits epithelial hyperplasia, reinforces the apoptosis of activated T cells, and inhibits the chemotaxis of neutrophils. In addition, the drug decreases the synthesis of a range of proinflammatory cytokines such as TNF-α and IL-1. Folic acid supplementation may prevent or reduce a range of adverse reactions associated with MTX treatment of psoriasis .
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But it can help to combine medical treatment with home remedies to help reduce scalp psoriasis symptoms. However, effectiveness of systemic administration of these drugs on psoriasis has not been established.